Big Mouth

Nick Kroll

Nick Birch / Maury the Hormone Monster / Coach Steve / Lola Skumpy / Rick the Hormone Monster (voice)

John Mulaney

Andrew Glouberman (voice)

Jessi Klein

Jessi Glaser (voice)

Jason Mantzoukas

Jay Bilzerian (voice)

Maya Rudolph

Diane Birch / Connie the Hormone Monstress (voice)

Fred Armisen

Elliot Birch (voice)

Jordan Peele

Ghost of Duke Ellington (voice)

Andrew Rannells

Matthew (voice)

Jenny Slate

Missy Foreman-Greenwald (voice)

Joe Wengert

Caleb / Pornscape Residents (voice)

Ayo Edebiri

Missy Foreman-Greenwald / Mosaic Missy (voice)

June Diane Raphael

Richard Kind

Jessica Chaffin

Shannon Glaser (voice)

Paula Pell

Barbara Glouberman (voice)

Neil Casey

Jon Daly

Jak Knight

DeVon / Gina's Brother #2 (voice)

Chelsea Peretti

Diaphragm (voice)

Seth Morris

Mark Rivers

Michael Stipe Tampon (voice)

Gil Ozeri

Nathan Fillion

Kat Dennings

Leah Birch / Lorraine the Hormone Monstress (voice)

Gina Rodriguez

Gina Alvarez / Gina Parrot (voice)

David Thewlis

Shame Wizard (voice)

Thandiwe Newton

Mona (voice)

Maria Bamford

Tito the Anxiety Mosquito (voice)

Heather Lawless

Jenna Bilzerian (voice)

Brandon Kyle Goodman

Walter the Lovebug (voice)

Mark Duplass

Whitmer Thomas

Paul Scheer

Ali Wong

Ali (voice)

Zachary Quinto

Aiden (voice)

Stephanie Beatriz

Emily Altman

Milk (voice)

Chloe Fineman

Rob Huebel

Mr. Lizer (voice)

Natasha Lyonne

Ms. Dunn (voice)

Gary Cole

Matthew's Father (voice)

Jean Smart

Depression Kitty (voice)

Jack McBrayer

Jack (voice)

John Gemberling

Security Guard / Bus Driver's Son (voice)

Craig Robinson

End Credits Singer (voice)

Michaela Watkins

Cantor Dina Reznick (voice)

Fran Gillespie

Girl (voice)

Kristen Bell

Uninterested Girl (voice)

Ashley London

Kitty / DNA Expert / Pornscape Residents (voice)

Zach Woods

Rosa Salazar

Ms. Benitez (voice)

Quinta Brunson

Ayden Mayeri

Gabrielle / Freshman (voice)

Andy Daly

Dr. Wendy Engle / Motel Pillow #1 (voice)

Bobby Cannavale

Gavin (voice)

John Oliver

Harry (voice)

Seth Rogen

Seth Goldberg (voice)

Julie White

Kimberly (voice)

Sterling K. Brown

Michael Angelo (voice)

Crissy Guerrero

Kristen Wiig

Jessi's Vagina (voice)

Lena Waithe

Megan Thee Stallion

Megan the(e?) Hormone Monstress (voice)

Patrick Page

Dread (voice)

Ileen Goldsmith

Jessi Glaser - singing double / Judd's Girlfriend (voice)

Brendan McCreary

Ghost of Freddie Mercury (voice)

Carlos Alazraqui

Gustavo (voice)

Julie Klausner

Cherry Marashina (voice)

Chris Redd

(voice)

Josie Totah

Natalie (voice)

Joel Kim Booster

Charles Lu (voice)

Judd Hirsch

Lewis Glouberman (voice)

Beck Bennett

Owen (voice)

Billy Porter

J Valerione

B-High Qee-Choi Member (voice)

Keke Palmer

Aidy Bryant

Emmy (voice)

Rosie Perez

Petra (voice)

Mitra Jouhari

Juliet Mills

Pamela Adlon

Sonya the Lovebug (voice)

Jon Hamm

Scallops (voice)

Jon Gabrus

Movie Theater Customer (voice)

Anna Graves

Mrs. Albert (voice)

Nasim Pedrad

Fatima (voice)

Mae Whitman

Tallulah Levine (voice)

Chrissy Guerrero

Choir Girl (voice)

Philip Quinaz

Tanya Alvarez (voice)

Harvey Fierstein

Older Guy Town Resident (voice)

Jerry Minor

Man #3 / Singing Fish (voice)

Piotr Michael

Siamese Twin #2 (voice)

Marisa Lark Wallin

Reese's Wertherspoon / Woman (voice)

Martin Short

Gordie (voice)

David Cross

Skip Glouberman (voice)

Carol Kane

Menopause Banshee / Old Woman (voice)

Tawny Newsome

(voice)

Retta

Duke's Mother (voice)

Wanda Sykes

Ghost of Harriet Tubman (voice)

Jaboukie Young-White

(voice)

Rob Riggle

Sgt. Adderall (voice)

Bobby Berk

Bobby Berk (voice)

Karamo Brown

Karamo Brown (voice)

Tan France

Tan France (voice)

Antoni Porowski

Antoni Porowski (voice)

Jonathan Van Ness

Jonathan Van Ness (voice)

Anna Konkle

Izzy (voice)

Maya Erskine

Misha (voice)

Alia Shawkat

Roland (voice)

Paul Giamatti

Andrew’s Shit (voice)

Adam Scott

Mr. Dylan Keating (voice)

Hugh Jackman

himself (voice)

Kumail Nanjiani

himself (voice)

Jemaine Clement

Simon Sex (voice)

Kristen Schaal

Bernie Sanders (voice)

Somali Rose

Missy’s Overalls

Lupita Nyong'o

Asha (voice)

Miranda Tapsell

Kara (voice)

Lin-Manuel Miranda

Puerto Rican Pubic Hair (voice)

Randall Park

Pete Doheny (voice)

Maitreyi Ramakrishnan

Marissa (voice)

Ava Lalezarzadeh

Nazanin (voice)

Don Cheadle

Don Cheadle (voice)

Padma Lakshmi

Priya (voice)

Zach Galifianakis

Gratitoad (voice)

Jeff Goldblum

The Apple Brooch

Steve Buscemi

Skyla I'Lece

Katie Kreshek

Violet Rivers

Larry Owens

Holly Hunter

James III

Franny London

Cynthia Erivo

Andrew Goldberg

Eliseo Román

Eliseo Román (voice)